LYMPHOID NEOPLASIA T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients
نویسندگان
چکیده
1Feinstein Institute for Medical Research, North Shore-LIJ Health System, Manhasset, NY; 2Department of Medicine, North Shore University Hospital, North Shore-LIJ Health System, Manhasset, NY; 3Department of Medicine, Hofstra North Shore-LIJ School of Medicine, New York, NY; 4Department of Medicine, Long Island Jewish Medical Center, North Shore-LIJ Health System, New Hyde Park, NY; and 5Department of Molecular Medicine, Hofstra North Shore-LIJ School of Medicine, New York, NY
منابع مشابه
T-cell independent, B-cell receptor-mediated induction of telomerase activity differs among IGHV mutation-based subgroups of chronic lymphocytic leukemia patients.
Although B-cell chronic lymphocytic leukemia (B-CLL) clones with unmutated IGHV genes (U-CLL) exhibit greater telomerase activity than those with mutated IGHV genes (M-CLL), the extent to which B-cell receptor (BCR) triggering contributes to telomerase up-regulation is not known. Therefore, we studied the effect of BCR stimulation on modulating telomerase activity. The multivalent BCR ligand, d...
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